Cerebral regional oxygen saturation during cardiopulmonary resuscitation and return of spontaneous circulation: A systematic review and meta-analysis

Abstract Aim Predicting the return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation in victims cardiac arrest (CA) remains challenging. Cerebral regional oxygen saturation (rSO2) measured is feasible, and higher initial overall values seem associated with ROSC. However, these observations were limited to analysis few small single-centre studies. There a growing number studies evaluating role cerebral rSO2 prediction Methods We conducted an updated meta-analysis aimed at investigating association ROSC after CA. performed subgroups analyses according location CA secondary country where study was (resuscitation practice varies greatly for out-of-hospital CA). Results included 17 Higher (11 studies, n?=?2870, 16.6% achieved ROSC) ROSC: Mean Difference (MD) -11.54 [95%Confidence Interval (CI)-20.96, -2.12]; p?=?0.02 (I2?=?97%). The confirmed this finding when pooling together European USA but did not Japanese (p?=?0.06). One multi-centre outlier large influence on 95%CI. (9 n?=?894, 33.7% achieving MD-10.38; [-13.73, -7.03]; p? Conclusions This between we found geographical differences, since present analysed separately. Keywords near infrared spectrometry; advanced life support; order; resuscitation.